The Seattle Mariners (8-8) and the Cincinnati Reds (8-8) open a 3-game series Tuesday at Great American Ball Park. First pitch is scheduled for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Mariners vs. Reds odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting; Seattle won 3-0 last season
Seattle extended its win streak to 4 games with a 3-game sweep of the Texas Rangers, capping the series with a 3-1 win Sunday as a -141 home favorite. C Cal Raleigh’s 2-run homer in the first inning proved decisive, and LF Randy Arozarena added an insurance run in the sixth after being hit by a pitch with the bases loaded.
Cincinnati pushed its win streak to 3 games and has now taken 5 of its last 6 after completing a 3-game sweep of the Pittsburgh Pirates with Sunday’s 4-0 win as a -175 home favorite. The top of the Reds’ order accounted for all 4 RBIs, highlighted by 2B Santiago Espinal’s 2-run single in the third inning. The Reds held Pittsburgh to just 2 hits in the shutout.
Mariners at Reds projected starters
RHP Luis Castillo vs. LHP Nick Lodolo
Castillo (1-1, 2.12 ERA) makes his fourth start. He has a 1.12 WHIP, 3.2 BB/9 and 7.9 K/9 through 17 innings.
- Last start: No-decision, 5 IP, 0 ER, 5 H, 2 BB, 6 K in 2-1 home setback in 12 innings vs. Houston Astros Tuesday
- 2024 road stats: 4-7, 4.25 ERA (78 1/3 IP, 37 ER), 1.28 WHIP, 7.8 K/9 in 14 starts
- Played for Reds for first 5½ years of his career before being traded to Mariners
- Has never faced Reds
Lodolo (2-1, 0.96 ERA) makes his fourth start. He has a 0.70 WHIP, 0.5 BB/9 and 3.9 K/9 through 18 2/3 innings.
- Last start: Win, 6 IP, 0 ER, 3 H, 1 BB, 3 K in 1-0 victory at San Francisco Giants Tuesday
- 2025 home stats: 1 start, win, 6 IP, 2 ER, 5 H, 0 BB, 1 K in 3-2 victory vs. Giants March 29
- Has never faced Mariners
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Mariners at Reds odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:18 a.m. ET.
- Moneyline (ML): Mariners -120 (bet $120 to win $100) | Reds +100 (bet $100 to win $100)
- Run line (RL)/Against the spread (ATS): Mariners -1.5 (+145) | Reds +1.5 (-175)
- Over/Under (O/U): 8.5 (O: -120 | U: +100)
Mariners at Reds picks and predictions
Prediction
Reds 4, Mariners 3
Moneyline
BET REDS (+100).
Both teams enter Tuesday coming off series sweeps, but the Reds have the edge playing at home. Cincinnati has caught fire over its last 2 series, winning 5 of 6 with 3 shutouts and allowing 3 runs or fewer in each of those victories. The Mariners will pose a challenge — especially with Castillo making his first start in Cincinnati since being traded in 2022 — but the Reds should notch their first win over Seattle in more than a year.
Run line/Against the spread
PASS.
There is no value on the Reds’ run line.
Over/Under
BET UNDER 8.5 (+100).
This matchup features a pair of aces on the mound. Castillo has surrendered just 4 earned runs across his first 3 starts, with the Mariners allowing 2 runs or fewer in each of his last 2 outings.
Lodolo has been dominant, tied for the second-lowest ERA in baseball at 0.96 and ranking fifth in WHIP at 0.70. He’s allowed just 2 earned runs across 3 starts, with none in his last 2. The Reds have held opponents to 2 or fewer runs in each of his outings.
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